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Article

SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

Cell - 20 Apr 1990

Fedor-Chaiken M, Deschenes R J, Broach J R

Abstract excerpt

We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production of cAMP following stimulation by an activated RAS allele. Null mutations of srv2 result in...

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PMID: 2158860
DOI: 10.1016/0092-8674(90)90813-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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SRV2, a gene required for RAS activation of adenylate cyclase in yeast.PMID 2158860Read ↗

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