SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

doi:10.1016/0092-8674(90)90813-t

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Article

SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

Cell - 20 Apr 1990

Fedor-Chaiken M, Deschenes R J, Broach J R

Abstract excerpt

We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production of cAMP following stimulation by an activated RAS allele. Null mutations of srv2 result in...

Topics

Adenylyl Cyclases
Amino Acid Sequence
Base Sequence
Cell Cycle
Cloning, Molecular
Cyclic AMP
DNA, Fungal
Enzyme Activation
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Molecular Sequence Data

Mutation

Restriction Mapping

Saccharomyces cerevisiae

ras Proteins

Source

Open in PubMed

Identifiers

PMID: 2158860
DOI: 10.1016/0092-8674(90)90813-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2158860-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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SRV2, a gene required for RAS activation of adenylate cyclase in yeast.PMID 2158860Read ↗

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