Article
Dominant lethal mutations in a conserved loop in 16S rRNA.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Powers T, Noller H F
Abstract excerpt
The 530 stem-loop region in 16S rRNA is among the most phylogenetically conserved structural elements in all rRNAs, yet its role in protein synthesis remains mysterious. G-530 is protected from kethoxal attack when tRNA, or its 15-nucleotide anticodon stem-loop fragment, is bound to the ribosomal A site. Based on presently available evidence, however, this region is believed to be too remote from the decoding...
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