Dominant lethal mutations in a conserved loop in 16S rRNA.

doi:10.1073/pnas.87.3.1042

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Article

Dominant lethal mutations in a conserved loop in 16S rRNA.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Powers T, Noller H F

Abstract excerpt

The 530 stem-loop region in 16S rRNA is among the most phylogenetically conserved structural elements in all rRNAs, yet its role in protein synthesis remains mysterious. G-530 is protected from kethoxal attack when tRNA, or its 15-nucleotide anticodon stem-loop fragment, is bound to the ribosomal...

Topics

Base Sequence
DNA, Ribosomal
Escherichia coli
Gene Expression
Genes, Bacterial
Genes, Dominant
Genes, Lethal
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Plasmids
Polyribosomes
RNA, Ribosomal
RNA, Ribosomal, 16S
Restriction Mapping

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