Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

1 Jun 2013

Abstract excerpt

Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Skin Protection and Aging
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24052939
DOI: 10.1016/j.stemcr.2013.04.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere DysfunctionPMID 24052939Read ↗

Radiation sensitivity increases with proliferation‐associated telomere dysfunction in nontransformed human epithelial cellsSemantic proximity Read ↗

Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia.Semantic proximity Read ↗

The potential utility of telomere‐related markers for cancer diagnosisSemantic proximity Read ↗

Telomere dysfunction drives chromosomal instability in human mammary epithelial cellsSemantic proximity Read ↗

Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutationsSemantic proximity Read ↗

Germline <i>BRCA1</i> Mutation Deregulates Irradiation–Induced Cell Cycle Checkpoints in Human Mammary Luminal ProgenitorsSemantic proximity Read ↗

Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and CarcinogenesisSemantic proximity Read ↗

Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissueSemantic proximity Read ↗

Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Semantic proximity Read ↗

Proof of region-specific multipotent progenitors in human breast epitheliaSemantic proximity Read ↗

Mammary stem cells and progenitors: targeting the roots of breast cancer for preventionSemantic proximity Read ↗

Concise Review: Telomere Biology in Normal and Leukemic Hematopoietic Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.