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Article

Telomere dysfunction drives chromosomal instability in human mammary epithelial cells

28 Jul 2005

Abstract excerpt

The development of genomic instability is an important step toward generating the multiple genetic changes required for cancer. Telomere dysfunction is one of the factors that contribute to tumorigenesis. Telomeres shorten with each cell division in the absence of telomerase. Human mammary epithelial cells (HMECs) obtained from normal human tissue demonstrate two growth phases. After an initial phase of active...

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PMID: 16052508
DOI: 10.1002/gcc.20244

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