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Article

Polymorphisms in the endothelial protein C receptor gene and thrombophilia.

Thrombosis and haemostasis - 1 Sept 2007

Medina Pilar, Navarro Silvia, Estellés Amparo, España Francisco

Abstract excerpt

The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. Once formed, activated protein C (APC) down-regulates thrombin formation by inactivating factors (F)Va and FVIIIa. Endothelial protein C receptor (EPCR) is able to bind protein C and increase the rate of...

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Identifiers

PMID: 17849044

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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