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Article

Inherited abnormalities in the protein C activation pathway.

Pathophysiology of haemostasis and thrombosis - 1 Jan 2000

España Francisco, Medina Pilar, Navarro Silvia, Estellés Amparo, Aznar Justo

Abstract excerpt

The protein C (PC) anticoagulant pathway plays a crucial role in the regulation of fibrin formation via proteolytic degradation of the procoagulant cofactors factor Va and VIIIa by activated PC (APC). PC circulates in plasma as a zymogen, which is activated, on the surface of endothelial cells by...

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PMID: 13679649
DOI: 10.1159/000073573

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-13679649-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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