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Article

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.

Nature communications - 7 Jun 2021

Moyon Sarah, Frawley Rebecca, Marechal Damien, Huang Dennis, Marshall-Phelps Katy L H, Kegel Linde, Bøstrand Sunniva M K, Sadowski Boguslawa, Jiang Yong-Hui, Lyons David A, Möbius Wiebke, Casaccia Patrizia

Abstract excerpt

The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and defective in old mice. Constitutive and inducible oligodendrocyte lineage-specific ablation of Tet1 (but not of Tet2), recapitulate this age-related decline in repair...

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Identifiers

PMID: 34099715
DOI: 10.1038/s41467-021-23735-3
PMCID: PMC8185117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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