Article
Analysis of a Chinese hamster ovary cell mutant with defective mobilization of cholesterol from the plasma membrane to the endoplasmic reticulum.
Journal of lipid research - 1 Oct 1997
Jacobs N L, Andemariam B, Underwood K W, Panchalingam K, Sternberg D, Kielian M, Liscum L
Abstract excerpt
The factors involved in shuttling cholesterol among cellular membranes have not been defined. Using amphotericin B selection, we previously isolated Chinese hamster ovary cell mutants expressing defects in intracellular cholesterol transport. Complementation analysis among seven mutants identifie...
Topics
- Amphotericin B
- Animals
- Biological Transport
- CHO Cells
- Cell Division
- Cell Membrane
- Cholesterol
- Cholesterol Esters
- Cholesterol Oxidase
- Cholesterol, LDL
- Cricetinae
- Endoplasmic Reticulum
- Lipoproteins, LDL
- Lysosomes
- Membrane Fusion
- Mutation
- Phospholipids
- Sphingomyelin Phosphodiesterase