DNA structure, mutations, and human genetic disease.

doi:10.1016/0958-1669(92)90005-4

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Article

DNA structure, mutations, and human genetic disease.

Current opinion in biotechnology - 1 Dec 1992

Sinden R R, Wells R D

Abstract excerpt

The etiology of fragile X syndrome, myotonic dystrophy and Kennedy's disease has been attributed to the massive expansion of triplet repeat DNA sequences. This review details the relationships between the structural diversity of DNA, its secondary structure or DNA-directed mutagenesis, and the ex...

Topics

Base Sequence
DNA
Gene Deletion
Genetic Diseases, Inborn
Humans
Models, Molecular
Mutation
Nucleic Acid Conformation
Point Mutation
Recombination, Genetic

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