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Article

Cell-surface expression of a new splice variant of the mouse signal peptide peptidase.

Biochimica et biophysica acta - 1 Jan 2000

Urny Jens, Hermans-Borgmeyer Irm, Schaller H Chica

Abstract excerpt

The signal peptide peptidase (SPP) is an intramembrane-cleaving aspartyl protease that acts on type II transmembrane proteins. SPP substrates include signal peptides after they have been cleaved from a preprotein, hence the name. The known SPP isoform, which we renamed SPPalpha, contains an endoplasmic reticulum retention signal at the carboxy terminus. We found a new splice variant, SPPbeta, with an additional...

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PMID: 16730383
DOI: 10.1016/j.bbaexp.2006.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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