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Article

Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2021

Gradtke Ann-Christine, Mentrup Torben, Lehmann Christian H K, Cabrera-Cabrera Florencia, Desel Christine, Okakpu Darian, Assmann Maike, Dalpke Alexander, Schaible Ulrich E, Dudziak Diana, Schröder Bernd

Abstract excerpt

Signal peptide peptidase-like 2a (SPPL2a) is an aspartyl intramembrane protease essential for degradation of the invariant chain CD74. In humans, absence of SPPL2a leads to Mendelian susceptibility to mycobacterial disease, which is attributed to a loss of the dendritic cell (DC) subset conventional DC2. In this study, we confirm depletion of conventional DC2 in lymphatic tissues of SPPL2a-/- mice and demonstrate...

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PMID: 33239420
DOI: 10.4049/jimmunol.2000151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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