Article

The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

2022-01-21

Abstract excerpt

<h4>ABSTRACT</h4> The mammalian gene Brain-Derived Neurotrophic Factor (BDNF) is an essential mediator of brain assembly, development, and maturation which has been implicated in a variety of brain disorders such as neurodevelopmental disorders (e.g. autism spectrum disorder), neuropsychiatric disorders (e.g. depression, PTSD, schizophrenia), and neurodegenerative disorders (e.g. Parkinson’s). Loss of BDNF during...

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Literature Corpus work: 210e9d9a-dd9f-5566-a86a-be2c05bbb4ec
DOI: 10.1101/2022.01.21.477254

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