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Article

Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation.

International journal of molecular sciences - 17 Sept 2013

Cristóvão Joana S, Leal Sónia S, Cardoso Isabel, Gomes Cláudio M

Abstract excerpt

Superoxide dismutase 1 (SOD1) aggregation is one of the pathological markers of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. The underlying molecular grounds of SOD1 pathologic aggregation remains obscure as mutations alone are not exclusively the cause for the formation of protein inclusions. Thus, other components in the cell environment likely play a key role in triggering SOD1...

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Source

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Identifiers

PMID: 24048249
DOI: 10.3390/ijms140919128
PMCID: PMC3794824

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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