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Article

Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival.

PLoS biology - 29 Jul 2008

Wang Qi, Johnson Joshua L, Agar Nathalie Y R, Agar Jeffrey N

Abstract excerpt

The nature of the "toxic gain of function" that results from amyotrophic lateral sclerosis (ALS)-, Parkinson-, and Alzheimer-related mutations is a matter of debate. As a result no adequate model of any neurodegenerative disease etiology exists. We demonstrate that two synergistic properties, namely, increased protein aggregation propensity (increased likelihood that an unfolded protein will aggregate) and...

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Identifiers

PMID: 18666828
DOI: 10.1371/journal.pbio.0060170
PMCID: PMC2486295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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