Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS.

PloS one - 4 Apr 2011

Wuolikainen Anna, Moritz Thomas, Marklund Stefan L, Antti Henrik, Andersen Peter Munch

Abstract excerpt

BACKGROUND/AIM: The changes in the cerebrospinal fluid (CSF) metabolome associated with the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) are poorly understood and earlier smaller studies have shown conflicting results. The metabolomic methodology is suitable for screening large cohorts of samples. Global metabolomics can be used for detecting changes of metabolite concentrations in samples...

Topics

Join the communities discussing this publication.

Amyotrophic Lateral Sclerosis
Case-Control Studies
Gas Chromatography-Mass Spectrometry
Genotype
Metabolome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Superoxide Dismutase

Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 21483737
DOI: 10.1371/journal.pone.0017947
PMCID: PMC3070699

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS.PMID 21483737Read ↗

ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations.Semantic proximity Read ↗

Metabolomics: A Tool to Understand the Impact of Genetic Mutations in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Biomarkers for amyotrophic lateral sclerosis.Semantic proximity Read ↗

Unveiling amyotrophic lateral sclerosis complexity: insights from proteomics, metabolomics, and microbiomicsSemantic proximity Read ↗

Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations.Semantic proximity Read ↗

Identification of a Distinct Metabolomic Subtype of Sporadic ALS PatientsSemantic proximity Read ↗

Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosisSemantic proximity Read ↗

Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohortSemantic proximity Read ↗

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosisSemantic proximity Read ↗

Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosisSemantic proximity Read ↗

Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative updateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.