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Article

A faulty interaction between SOD1 and hCCS in neurodegenerative disease.

Scientific reports - 10 Jun 2016

Wright Gareth S A, Antonyuk Svetlana V, Hasnain S Samar

Abstract excerpt

A proportion of Amyotrophic lateral sclerosis (ALS) cases result from impaired mutant superoxide dismutase-1 (SOD1) maturation. The copper chaperone for SOD1 (hCCS) forms a transient complex with SOD1 and catalyses the final stages of its maturation. We find that a neurodegenerative disease-associated hCCS mutation abrogates the interaction with SOD1 by inhibiting hCCS zinc binding. Analogously, SOD1 zinc loss...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27282955
DOI: 10.1038/srep27691
PMCID: PMC4901319

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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