Article

A widespread family of bacterial gene clusters produces ClpP inhibitors

2021-05-27

Abstract excerpt

<title>Abstract</title> <p>Intracellular proteolytic complexes play an essential role in modeling the proteome in both bacteria and eukaryotes. ClpP is the protease subunit of one such highly conserved proteolytic complex that, despite its potential, remains unexploited as a drug target. Here we describe a target-directed genome mining strategy to identify ClpP targeting compounds from the bacterial order Actinom...

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Literature Corpus work: 4b61865c-e46e-5346-bdee-4fc0c000bafa
DOI: 10.21203/rs.3.rs-464484/v1

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