Article
Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2013
Wang Hansong, Taverna Darin, Stram Daniel O, Fortini Barbara K, Cheng Iona, Wilkens Lynne R, Burnett Terrilea, Makar Karen W, Lindor Noralane M, Hopper John L, Gallinger Steve, Baron John A, Haile Robert, Kolonel Laurence N, Henderson Brian E, Newcomb Polly A, Casey Graham, Duggan David, Ulrich Cornelia M, Le Marchand Loïc
Abstract excerpt
BACKGROUND: It is widely accepted that chronic inflammation plays a role in the etiology of colorectal cancer. Using a two-stage design, we examined the associations between colorectal cancer and common variation in 37 key genes in the inflammation and innate immunity pathways. METHODS: In the discovery stage, 2,322 discordant sibships (2,535 cases, 3,915 sibling controls) from the Colorectal Cancer Family...
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