Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations.

doi:10.1093/mutage/geae008

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Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations.

Mutagenesis - 15 Mar 2025

Mandle Hannah B, Jenab Mazda, Gunter Marc J, Tjønneland Anne, Olsen Anja, Dahm Christina C, Zhang Jie, Sugier Pierre-Emmanuel, Rothwell Joseph, Severi Gianluca, Kaaks Rudolf, Katzke Verena A, Schulze Matthias B, Masala Giovanna, Sieri Sabina, Panico Salvatore, Sacerdote Carlotta, Bonet Catalina, Sánchez Maria-Jose, Amiano Pilar, Huerta José María, Guevara Marcela, Palmqvist Richard, Löwenmark Thyra, Perez-Cornago Aurora, Weiderpass Elisabete, Heath Alicia K, Cross Amanda J, Vineis Paolo, Hughes David J, Fedirko Veronika

Abstract excerpt

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn's disease with colon and rectal cancer risks. Incident CRC cases (N = 1374;...

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PMID: 38441165
DOI: 10.1093/mutage/geae008
PMCID: PMC11911009

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CRP
TLR4
IL10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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