Article
Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes.
Journal of molecular and cellular cardiology - 1 Nov 2012
Tufan Hale, Zhang Xiao-Hua, Haghshenas Nicole, Sussman Mark A, Cleemann Lars, Morad Martin
Abstract excerpt
Stem cell transplantation has been successfully used for amelioration of cardiomyopathic injury using adult cardiac progenitor cells (CPC). Engineering of mouse CPC with the human serine/threonine kinase Pim-1 (CPCeP) enhances regeneration and cell survival in vivo, but it is unknown if such apparent lineage commitment is associated with maturation of electrophysiological properties and excitation-contraction...
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