Article
Cardiac primitive cells become committed to a cardiac fate in adult human heart with chronic ischemic disease but fail to acquire mature phenotype: genetic and phenotypic study.
Basic research in cardiology - 1 Jan 2013
Nurzynska Daria, Di Meglio Franca, Romano Veronica, Miraglia Rita, Sacco Anna Maria, Latino Francesca, Bancone Ciro, Della Corte Alessandro, Maiello Ciro, Amarelli Cristiano, Montagnani Stefania, Castaldo Clotilde
Abstract excerpt
Adult human heart hosts a population of cardiac primitive CD117-positive cells (CPCs), which are responsible for physiological tissue homeostasis and regeneration. While the bona fide stem cells express telomerase, their progenies are no longer able to preserve telomeric DNA; hence the balance between their proliferation and differentiation has to be tightly controlled in order to prevent cellular senescence and...
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