Article
Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles.
PloS one - 1 Jan 2011
Settles Marcus, Etzrodt Martin, Kosanke Katja, Schiemann Matthias, Zimmermann Alexander, Meier Reinhard, Braren Rickmer, Huber Armin, Rummeny Ernst J, Weissleder Ralph, Swirski Filip K, Wildgruber Moritz
Abstract excerpt
OBJECTIVE: To explore the capacity of human CD1⁺CD16⁺⁺ and CD14⁺⁺CD16⁻ monocytes to phagocyte iron-oxide nanoparticles in vitro. METHODS: Human monocytes were labeled with four different magnetic nanoparticle preparations (Ferumoxides, SHU 555C, CLIO-680, MION-48) exhibiting distinct properties and cellular uptake was quantitatively assessed by flow cytometry, fluorescence microscopy, atomic absorption...
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