Article
Mechanism of hard-nanomaterial clearance by the liver.
Nature materials - 1 Nov 2016
Tsoi Kim M, MacParland Sonya A, Ma Xue-Zhong, Spetzler Vinzent N, Echeverri Juan, Ouyang Ben, Fadel Saleh M, Sykes Edward A, Goldaracena Nicolas, Kaths Johann M, Conneely John B, Alman Benjamin A, Selzner Markus, Ostrowski Mario A, Adeyi Oyedele A, Zilman Anton, McGilvray Ian D, Chan Warren C W
Abstract excerpt
The liver and spleen are major biological barriers to translating nanomedicines because they sequester the majority of administered nanomaterials and prevent delivery to diseased tissue. Here we examined the blood clearance mechanism of administered hard nanomaterials in relation to blood flow dynamics, organ microarchitecture and cellular phenotype. We found that nanomaterial velocity reduces 1,000-fold as they...
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