Article
Technetium Tc 99m sulfur colloid phenotypic probe for the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin in women with ovarian cancer.
Cancer chemotherapy and pharmacology - 1 Mar 2016
Giovinazzo Hugh, Kumar Parag, Sheikh Arif, Brooks Kristina M, Ivanovic Marija, Walsh Mark, Caron Whitney P, Kowalsky Richard J, Song Gina, Whitlow Ann, Clarke-Pearson Daniel L, Brewster Wendy R, Van Le Linda, Zamboni Beth A, Bae-Jump Victoria, Gehrig Paola A, Zamboni William C
Abstract excerpt
PURPOSE: Significant variability in the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin (PLD) exists. PLD undergoes clearance via the mononuclear phagocyte system (MPS). Technetium Tc 99m sulfur colloid (TSC) is approved for imaging MPS cells. We investigated TSC as a phenotypic probe of PLD pharmacokinetics and pharmacodynamics in women with epithelial ovarian cancer. METHODS: TSC 10 mCi...
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