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Article

Macrophage Phenotype-Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles.

Small (Weinheim an der Bergstrasse, Germany) - 1 Apr 2026

He Tianchang, Zhu Lina, Ding Jiayi, Fang Xiaoyan, Gao Yu, Mailänder Volker, Crespy Daniel, Landfester Katharina, Jiang Shuai

Abstract excerpt

The phenotype of source cells used for membrane coating fundamentally influences the biointerfacing behavior of cell membrane-coated nanoparticles. Meanwhile, the formation of a protein corona (PC) in biological fluids plays a pivotal role in dictating the in vivo fate of nanoparticles. Yet, how macrophage phenotypes influence PC composition and, in turn, dictate the clearance of biomimetic nanoparticles remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41718688
DOI: 10.1002/smll.202514389
PMCID: PMC13089100

Genes

PC
C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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