Article
A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA).
PloS one - 1 Jan 2017
Cannone Valentina, Scott Christopher G, Decker Paul A, Larson Nicholas B, Palmas Walter, Taylor Kent D, Wang Thomas J, Gupta Deepak K, Bielinski Suzette J, Burnett John C
Abstract excerpt
In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome. The observed phenotype is consistent with the blood pressure lowering and metabolic...
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