Article
The -665 C>T polymorphism in the eNOS gene predicts cardiovascular mortality and morbidity in white Europeans.
Journal of human hypertension - 1 Mar 2015
Olivi L, Gu Y M, Salvi E, Liu Y P, Thijs L, Velayutham D, Jin Y, Jacobs L, D'Avila F, Petit T, Barcella M, Lanzani C, Kuznetsova T, Manunta P, Barlassina C, Cusi D, Staessen J A
Abstract excerpt
We recently identified rs3918226 as a hypertension susceptibility locus (-665 C>T), TT homozygosity being associated with higher hypertension risk. T compared with C allele transfected cells had lower endothelial nitric oxide synthase (eNOS) expression. In the family-based Flemish Study on Environment, Genes and Health Outcomes (50.9% women; mean age 40.3 years), we investigated whether 32 TT homozygotes had...
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