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Article

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.

Gut - 1 Jul 2014

Wouters Mira M, Lambrechts Diether, Knapp Michael, Cleynen Isabelle, Whorwell Peter, Agréus Lars, Dlugosz Aldona, Schmidt Peter Thelin, Halfvarson Jonas, Simrén Magnus, Ohlsson Bodil, Karling Pontus, Van Wanrooy Sander, Mondelaers Stéphanie, Vermeire Severine, Lindberg Greger, Spiller Robin, Dukes George, D'Amato Mauro, Boeckxstaens Guy

Abstract excerpt

OBJECTIVE: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. DESIGN: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24041540
DOI: 10.1136/gutjnl-2013-304570

Genes

NXPH1
CDC42
LPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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