Article
Lessons learned--resolving the enigma of genetic factors in IBS.
Nature reviews. Gastroenterology & hepatology - 1 Feb 2016
Gazouli Maria, Wouters Mira M, Kapur-Pojskić Lejla, Bengtson May-Bente, Friedman Eitan, Nikčević Gordana, Demetriou Christiana A, Mulak Agata, Santos Javier, Niesler Beate
Abstract excerpt
IBS is the most prevalent functional gastrointestinal disorder and phenotypically characterized by chronic abdominal discomfort, pain and altered defecation patterns. The pathophysiology of IBS is multifactorial, albeit with a substantial genetic component. To date, studies using various methodologies, ranging from family and twin studies to candidate gene approaches and genome-wide association studies, have...
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