Article
The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
Journal of virology - 1 Feb 1990
Klimkait T, Strebel K, Hoggan M D, Martin M A, Orenstein J M
Abstract excerpt
A deletion mutation affecting vpu was introduced into an infectious molecular clone of human immunodeficiency virus type 1, and the resultant phenotype was examined after infection of human T lymphocytes. The absence of vpu resulted in an accumulation of cell-associated viral proteins and impaired the release of progeny virions. Both electron microscopic and biochemical analyses indicated that a large proportion...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cell Line
- Cell Survival
- Chromosome Deletion
- Genes, Viral
- HIV-1
- HeLa Cells
- Human Immunodeficiency Virus Proteins
- Humans