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Article

Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages.

The Journal of general virology - 1 Oct 2007

Richards Kathryn H, Clapham Paul R

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) vpu protein increases the release of virus particles from infected cells. Mutations that abrogate vpu function have a profound effect on HIV-1 replication in primary macrophage cultures. About 1.24 % of primary isolates in the HIV databases have vpu start-codon mutations. In addition, the envelope of the AD8 isolate was reported to compensate for the lack of vpu,...

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Source

Identifiers

PMID: 17872532
DOI: 10.1099/vir.0.83120-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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