Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.

Abstract excerpt

The phenotypes of a series of mutant human immunodeficiency virus type 1 proviruses with linker insertion and deletion mutations within the gag coding region were characterized. These mutants were tested for their ability to make and release viral particles in COS7 cells and for their viability in vivo. Of the 12 mutant proviruses, 4 did not make extracellular virion particles when transfected into COS7 cells....

Topics

• Amino Acid Sequence
• Cells, Cultured
• Gene Products, gag
• Genes, gag
• HIV Envelope Protein gp120
• HIV-1
• Humans
• Molecular Sequence Data
• Mutation
• RNA, Viral
• Virion