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Article

Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species.

Biochemical and biophysical research communications - 2 Oct 2015

Yu Suyeun, Jang Yeogil, Paik Donggi, Lee Eunil, Park Joong-Jean

Abstract excerpt

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells. However, Nmdmc physiological roles remain unveiled. We found that ubiquitous Nmdmc overexpression enhanced Drosophila lifespan and stress resistance. Interestingly, Nmdmc overexpression in the fat...

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Identifiers

PMID: 26319556
DOI: 10.1016/j.bbrc.2015.08.098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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