The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance.

doi:10.1371/journal.pone.0074151

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Article

The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance.

PloS one - 1 Jan 2013

Melis Melania, Atzori Elena, Cabras Stefano, Zonza Andrea, Calò Carla, Muroni Patrizia, Nieddu Mariella, Padiglia Alessandra, Sogos Valeria, Tepper Beverly J, Tomassini Barbarossa Iole

Abstract excerpt

Taste sensitivity to PROP varies greatly among individuals and is associated with polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform papilla density on the anterior tongue surface. Recently we showed that the PROP non-taster phenotype is strongly associated with the G variant of polymorphism rs2274333 (A/G) of the gene that controls the salivary trophic factor, gustin. The aims...

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PMID: 24040192
DOI: 10.1371/journal.pone.0074151
PMCID: PMC3767652

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