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Article

First objective evaluation of taste sensitivity to 6-n-propylthiouracil (PROP), a paradigm gustatory stimulus in humans.

Scientific reports - 11 Jan 2017

Sollai Giorgia, Melis Melania, Pani Danilo, Cosseddu Piero, Usai Ilenia, Crnjar Roberto, Bonfiglio Annalisa, Tomassini Barbarossa Iole

Abstract excerpt

Practical and reliable methods for the objective measure of taste function are critically important for studying eating behavior and taste function impairment. Here, we present direct measures of human gustatory response to a prototypical bitter compound, 6-n-propyltiouracil (PROP), obtained by electrophysiological recordings from the tongue of subjects who were classified for taster status and genotyped for the...

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Identifiers

PMID: 28074885
DOI: 10.1038/srep40353
PMCID: PMC5225483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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First objective evaluation of taste sensitivity to 6-n-propylthiouracil (PROP), a paradigm gustatory stimulus in humans.PMID 28074885Read ↗

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Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning.Semantic proximity Read ↗

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The gustin gene variation at rs2274333 and PROP taster status affect dietary fat perception: a stepwise multiple regression model study.Semantic proximity Read ↗

Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype.Semantic proximity Read ↗

The associations between 6-n-propylthiouracil (PROP) intensity and taste intensities differ by TAS2R38 haplotype.Semantic proximity Read ↗

Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype.Semantic proximity Read ↗

Genetic sensitivity to 6-n-propylthiouracil (PROP) and hedonic responses to bitter and sweet tastes.Semantic proximity Read ↗

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