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Article

Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.

PloS one - 1 Jan 2012

Cabras Tiziana, Melis Melania, Castagnola Massimo, Padiglia Alessandra, Tepper Beverly J, Messana Irene, Tomassini Barbarossa Iole

Abstract excerpt

Thiourea tasting can be predictive of individual differences in bitter taste responses, general food preferences and eating behavior, and could be correlated with saliva chemical composition. We investigated the possible relationship between PROP bitter taste responsiveness and the salivary prote...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22312435
DOI: 10.1371/journal.pone.0030962
PMCID: PMC3270025

Genes

PRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22312435-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.PMID 22312435Read ↗

Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects.Semantic proximity Read ↗

Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype.Semantic proximity Read ↗

Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection.Semantic proximity Read ↗

Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans.Semantic proximity Read ↗

Variation in the Ability to Taste Bitter Thiourea Compounds: Implications for Food Acceptance, Dietary Intake, and Obesity Risk in Children.Semantic proximity Read ↗

Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes.Semantic proximity Read ↗

Supertasting and PROP bitterness depends on more than the TAS2R38 gene.Semantic proximity Read ↗

Factors Influencing the Phenotypic Characterization of the Oral Marker, PROP.Semantic proximity Read ↗

Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype.Semantic proximity Read ↗

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.Semantic proximity Read ↗

Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells.Semantic proximity Read ↗

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