Article
Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells.
PloS one - 1 Jan 2013
Wang Xiyan, Liu Quentin, Hou Benxin, Zhang Wei, Yan Min, Jia Huimin, Li Haijun, Yan Dong, Zheng Feimeng, Ding Wei, Yi Chao, Hai Wang
Abstract excerpt
BACKGROUND: A major challenge in the treatment of pancreatic ductal adenocarcinoma is the failure of chemotherapy, which is likely due to the presence of the cancer stem cells (CSCs). OBJECTIVE: To identify side population (SP) cells and characterize s-like properties in human pancreatic cancer cell lines (h-PCCLs) and to exploit the efficacy of concomitant targeting of multiple key transcription factors...
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