Article
DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2.
Oncotarget - 30 Mar 2015
Qin Juan, Ji Jiao, Deng Rong, Tang Jun, Yang Fen, Feng Gong-Kan, Chen Wen-Dan, Wu Xiao-Qi, Qian Xiao-Jun, Ding Ke, Zhu Xiao-Feng
Abstract excerpt
Side population (SP) contains cancer stem-like cells (CSLCs). In this study, we characterized SP cells from nasopharyngeal carcinoma (NPC) cell lines and found that SP cells had a higher self-renewal ability in vitro and greater tumorigenicity in vivo. The AKT pathway was activated in NPC SP cells. DC120, a 2-pyrimidyl-5-amidothiazole inhibitor of the ATP binding site of AKT, inhibited phosphorylation of FKHRL1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.