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Article

Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects.

PloS one - 1 Jan 2013

Pino-Yanes María, Corrales Almudena, Cumplido José, Poza Paloma, Sánchez-Machín Inmaculada, Sánchez-Palacios Anselmo, Figueroa Javier, Acosta-Fernández Orlando, Buset Nisa, García-Robaina José Carlos, Hernández Mariano, Villar Jesús, Carrillo Teresa, Flores Carlos

Abstract excerpt

BACKGROUND: Before the advent of genome-wide association studies (GWAS), ADAM33, ADRB2, CD14, MS4A2 (alias FCER1B), IL13, IL4, IL4R, and TNF constituted the most replicated non-HLA candidate genes with asthma and related traits. However, except for the IL13-IL4 region, none of these genes have been found in close proximity of genome-wide significant hits among GWAS for asthma or related traits. Here we aimed to...

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Source

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Identifiers

PMID: 24039878
DOI: 10.1371/journal.pone.0073157
PMCID: PMC3767824

Genes

ADAM33
ADRB2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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