Article
Unifying candidate gene and GWAS Approaches in Asthma.
PloS one - 12 Nov 2010
Michel Sven, Liang Liming, Depner Martin, Klopp Norman, Ruether Andreas, Kumar Ashish, Schedel Michaela, Vogelberg Christian, von Mutius Erika, von Berg Andrea, Bufe Albrecht, Rietschel Ernst, Heinzmann Andrea, Laub Otto, Simma Burkhard, Frischer Thomas, Genuneit Jon, Gut Ivo G, Schreiber Stefan, Lathrop Mark, Illig Thomas, Kabesch Michael
Abstract excerpt
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS. We systematically identified 89 SNPs in 14 candidate genes previously associated with asthma in >3 independent study populations. We re-genotyped 39 SNPs in these...
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