Article
Association and interaction analyses of eight genes under asthma linkage peaks.
Allergy - 1 Nov 2009
Ferreira M A R, Zhao Z Z, Thomsen S F, James M, Evans D M, Postmus P E, Kyvik K O, Backer V, Boomsma D I, Martin N G, Montgomery G W, Duffy D L
Abstract excerpt
BACKGROUND: Linkage studies have implicated the 2q33, 9p21, 11q13 and 20q13 regions in the regulation of allergic disease. The aim of this study was to test genetic variants in candidate genes from these regions for association with specific asthma traits. METHODS: Ninety-five single nucleotide polymorphisms (SNP) located in eight genes (CD28, CTLA4, ICOS, ADAM23, ADAMTSL1, MS4A2, CDH26 and HRH3) were genotyped...
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