Article
Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.
Glia - 1 Nov 2013
Muñoz Diana Marcela, Tung Takyee, Agnihotri Sameer, Singh Sanjay, Guha Abhijit, Zadeh Gelareh, Hawkins Cynthia
Abstract excerpt
Gliomas are recognized as a heterogeneous group of neoplasms differing in their location and morphological features. These differences, between and within varying grades of gliomas, have not been explained solely on the grounds of an oncogenic stimulus. Interactions with the tumor microenvironment as well as inherent characteristics of the cell of origin are likely a source of this heterogeneity. There is an...
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