Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.

Cancer cell - 1 Aug 2005

Zhu Yuan, Guignard Frantz, Zhao Dawen, Liu Li, Burns Dennis K, Mason Ralph P, Messing Albee, Parada Luis F

Abstract excerpt

Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling. We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negati...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Neurofibromatosis 1

Share to Genes, p53

Share to Mice, Mutant Strains

Share to Penetrance

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 16098465
DOI: 10.1016/j.ccr.2005.07.004
PMCID: PMC3024718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16098465-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.PMID 16098465Read ↗

Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma.Semantic proximity Read ↗

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.Semantic proximity Read ↗

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model.Semantic proximity Read ↗

Mosaic analysis with double markers reveals tumor cell of origin in glioma.Semantic proximity Read ↗

Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (<i>NF1</i>) Is Insufficient for Astrocytoma FormationSemantic proximity Read ↗

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse ModelSemantic proximity Read ↗

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse ModelSemantic proximity Read ↗

Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications.Semantic proximity Read ↗

Molecular pathogenesis of adult brain tumors and the role of stem cells.Semantic proximity Read ↗

Injury primes mutation-bearing astrocytes for dedifferentiation in later life.Semantic proximity Read ↗

Convergence on BRAF and MAPK Signaling in Glioma Development in a P53-ENU modelSemantic proximity Read ↗

<i>Pten</i> Haploinsufficiency Accelerates Formation of High-Grade AstrocytomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.