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Article

Lack of association between COMT Val158Met polymorphism and late-onset Alzheimer's disease in Han Chinese.

Neuroscience letters - 25 Oct 2013

Zhou Jing, Li Xue-Mei, Jiang Teng, Liu Ying, Chi Song, Yu Jin-Tai, Tan Lan

Abstract excerpt

COMT (catechol-O-methyltransferase) has been conjectured to be associated with Alzheimer's disease (AD) due to its key role in cognitive function impairment by influencing the dopamine degradation in prefrontal cortex. A functional single nucleotide polymorphism (rs4680 SNP; G to A) in the COMT c...

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Source

Identifiers

PMID: 24035893
DOI: 10.1016/j.neulet.2013.09.006

Genes

COMT
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24035893-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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