Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.

doi:10.1002/art.39760

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Article

Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2016

Viatte Sebastien, Lee James C, Fu Bo, Espéli Marion, Lunt Mark, De Wolf Jack N E, Wheeler Lily, Reynolds John A, Castelino Madhura, Symmons Deborah P M, Lyons Paul A, Barton Anne, Smith Kenneth G C

Abstract excerpt

OBJECTIVE: Genetic variation in FOXO3 (tagged by rs12212067) has been associated with a milder course of rheumatoid arthritis (RA) and shown to limit monocyte-driven inflammation through a transforming growth factor β1-dependent pathway. This genetic association, however, has not been consistently observed in other RA cohorts. We sought to clarify the contribution of FOXO3 to prognosis in RA by combining detailed...

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PMID: 27214848
DOI: 10.1002/art.39760
PMCID: PMC5091631

Genes

FOXO3

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