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Article

Epistatic interactions determine the mutational pathways and coexistence of lineages in clonal Escherichia coli populations.

Evolution; international journal of organic evolution - 1 Sept 2013

Maharjan Ram Prasad, Ferenci Thomas

Abstract excerpt

Understanding how diversity emerges in a single niche is not fully understood. Rugged fitness landscapes and epistasis between beneficial mutations could explain coexistence among emerging lineages. To provide an experimental test of this notion, we investigated epistasis among four pleiotropic mutations in rpoS, mglD, malT, and hfq present in two coexisting lineages that repeatedly fixed in experimental...

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PMID: 24033182
DOI: 10.1111/evo.12137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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