Article
The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment.
Genomics - 1 Dec 2014
Chiotti Kami E, Kvitek Daniel J, Schmidt Karen H, Koniges Gregory, Schwartz Katja, Donckels Elizabeth A, Rosenzweig Frank, Sherlock Gavin
Abstract excerpt
The fitness landscape is a powerful metaphor for describing the relationship between genotype and phenotype for a population under selection. However, empirical data as to the topography of fitness landscapes are limited, owing to difficulties in measuring fitness for large numbers of genotypes under any condition. We previously reported a case of reciprocal sign epistasis (RSE), where two mutations individually...
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