Article
Genetic background affects epistatic interactions between two beneficial mutations.
Biology letters - 23 Feb 2013
Wang Yinhua, Arenas Carolina Díaz, Stoebel Daniel M, Cooper Tim F
Abstract excerpt
The phenotypic effect of mutations can depend on their genetic background, a phenomenon known as epistasis. Many experimental studies have found that epistasis is pervasive, and some indicate that it may follow a general pattern dependent on the fitness effect of the interacting mutations. These studies have, however, typically examined the effect of interactions between a small number of focal mutations in a...
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