Article
Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatedness.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2016
Wang Yinhua, Diaz Arenas Carolina, Stoebel Daniel M, Flynn Kenneth, Knapp Ethan, Dillon Marcus M, Wünsche Andrea, Hatcher Philip J, Moore Francisco B-G, Cooper Vaughn S, Cooper Tim F
Abstract excerpt
The effect of a mutation depends on its interaction with the genetic background in which it is assessed. Studies in experimental systems have demonstrated that such interactions are common among beneficial mutations and often follow a pattern consistent with declining evolvability of more fit genotypes. However, these studies generally examine the consequences of interactions between a small number of focal...
Topics
- Computer Simulation
- Ecosystem
- Epistasis, Genetic
- Escherichia coli
- Gene-Environment Interaction
- Genetic Fitness
- Models, Genetic
- Mutation
- Risk Assessment