Article
Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli.
Science (New York, N.Y.) - 21 Mar 2014
Plucain Jessica, Hindré Thomas, Le Gac Mickaël, Tenaillon Olivier, Cruveiller Stéphane, Médigue Claudine, Leiby Nicholas, Harcombe William R, Marx Christopher J, Lenski Richard E, Schneider Dominique
Abstract excerpt
Ecological opportunities promote population divergence into coexisting lineages. However, the genetic mechanisms that enable new lineages to exploit these opportunities are poorly understood except in cases of single mutations. We examined how two Escherichia coli lineages diverged from their common ancestor at the outset of a long-term coexistence. By sequencing genomes and reconstructing the genetic history of...
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